Publications

Neuronal Delivery of Antibodies has Therapeutic Effects in Animal Models of Botulism

Patrick M. McNutt , Edwin J. Vazquez-Cintron, Luis Tenezaca, Celinia A. Ondeck, Kyle E. Kelly, Mark Mangkhalakhili, James B. Machamer, Christopher A. Angeles, Elliot J. Glotfelty, Jaclyn Cika, Cesar H. Benjumea, Justin T. Whitfield, Philip A. Band, Charles B. Shoemaker, Konstantin Ichtchenko

Jan 2021

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Engineering Botulinum Neurotoxin C1 as a Molecular Vehicle for Intra-Neuronal Drug Delivery

Edwin J.Vazquez-Cintron, Phillip H. Beske, Luis Tenezaca, Bao Q.Tran, Jonathan M. Oyler, Elliot J.Glotfelty, Christopher A. Angeles, Aurelia Syngkon, Jean Mukherjee, Suzanne R. Kalb, Philip A. Band, Patrick M. McNutt, Charles B. Shoemaker, Konstantin Ichtchenko

Feb 2017

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Pre-Clinical Study of a Novel Recombinant Botulinum Neurotoxin Derivative Engineered for Improved Safety

Edwin Vazquez-Cintron, Luis Tenezaca, Christopher Angeles, Aurelia Syngkon,Victoria Liublinska, Konstantin Ichtchenko, Philip Band

Aug 2016

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Atoxic Derivative of Botulinum Neurotoxin A as a Prototype Molecular Vehicle for Targeted Delivery to the Neuronal Cytoplasm

Edwin J. Vazquez-Cintron, Maksim Vakulenko, Philip A. Band, Larry H. Stanker, Eric A. Johnson, Konstantin Ichtchenko

Jan 2014

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Neuronal Targeting, Internalization, and Biological Activity of a Recombinant Atoxic Derivative of Botulinum Neurotoxin A

Sabine Pelletta, William H.Tepp, Larry H.Stanker, Philip A.Band, Eric A.Johnson, Konstantin Ichtchenko

Feb 2012

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Recombinant Derivatives of Botulinum Neurotoxin A Engineered for Trafficking Studies and Neuronal Delivery

Philip A. Band, Steven Blais, Thomas A. Neubert, Timothy J. Cardozo, Konstantin Ichtchenko

Jan 2010

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Patents

European Union Patent #EP 3 230 457 B1: Clostridial Neurotoxin Fusion Proteins, Propeptide Fusions, their Expression, and Use

June 2021

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US Patent #9315549: Treatment Methods Using Atoxic Neurotoxin Derivatives

Apr 2016

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US Patent #8980284: Recombinant Derivatives of Botulinum Neurotoxins Engineered for Trafficking Studies and Neuronal Delivery

Mar 2015

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US Patent #8865186: Genetically Engineered Clostridial Genes, Proteins Encoded by the Engineered Genes, and Uses Thereof

Oct 2014

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US Patent #8044188: Genetically Engineered Clostridial Genes, Proteins Encoded by the Engineered Genes, and Uses Thereof

Oct 2011

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US Patent #7785606: Genetically Engineered Clostridial Genes, Proteins Encoded by the Engineered Genes, and Uses Thereof

Aug 2010

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Japanese Patent #7017932: Clostridial Neurotoxin Fusion Proteins, Propeptide Fusions, Their Expressions and Use 2022
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